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G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells
Glioblastoma (GBM) is an invariably fatal brain tumor in which a small subpopulation of self-renewable glioma stem cells (GSCs) contributes to tumor propagation and relapse. Targeting GSCs could therefore have a significant clinical impact for GBM. Telomestatin is a naturally-occurring compound that...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5176359/ https://ncbi.nlm.nih.gov/pubmed/26845351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2016.01.176 |
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