Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene, c-Myb

PURPOSE: Glioma stem cells (GSC) are a critical therapeutic target of glioblastoma multiforme (GBM). EXPERIMENTAL DESIGN: The effects of a G-quadruplex ligand, telomestatin, were evaluated using patient-derived GSCs, non-stem tumor cells (non-GSC), and normal fetal neural precursors in vitro and in...

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Detalhes bibliográficos
Main Authors: Miyazaki, Takeshi, Pan, Yang, Joshi, Kaushal, Purohit, Deepti, Hu, Bin, Demir, Habibe, Mazumder, Sarmistha, Okabe, Sachiko, Yamori, Takao, Viapiano, Mariano, Shin-ya, Kazuo, Seimiya, Hiroyuki, Nakano, Ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896097/
https://ncbi.nlm.nih.gov/pubmed/22230766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1795
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