Detection of COPB2 as a KRAS synthetic lethal partner through integration of functional genomics screens

Mutated KRAS plays an important role in many cancers. Although targeting KRAS directly is difficult, indirect inactivation via synthetic lethal partners (SLPs) is promising. Yet to date, there are no SLPs from high-throughput RNAi screening, which are supported by multiple screens. Here, we address...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Christodoulou, Eleni G., Yang, Hai, Lademann, Franziska, Pilarsky, Christian, Beyer, Andreas, Schroeder, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470967/
https://ncbi.nlm.nih.gov/pubmed/28415695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16079
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