Detection of COPB2 as a KRAS synthetic lethal partner through integration of functional genomics screens

Mutated KRAS plays an important role in many cancers. Although targeting KRAS directly is difficult, indirect inactivation via synthetic lethal partners (SLPs) is promising. Yet to date, there are no SLPs from high-throughput RNAi screening, which are supported by multiple screens. Here, we address...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Christodoulou, Eleni G., Yang, Hai, Lademann, Franziska, Pilarsky, Christian, Beyer, Andreas, Schroeder, Michael
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470967/
https://ncbi.nlm.nih.gov/pubmed/28415695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16079
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