L-Carnitine rescues ketamine-induced attenuated heart rate and MAPK (ERK) activity in zebrafish embryos

Ketamine, an antagonist of the N-methyl-D-aspartate (NMDA)-type glutamate receptors, is a pediatric anesthetic. Ketamine has been shown to be neurotoxic and cardiotoxic in mammals. Here, we show that after 2 h of exposure, 5 mM ketamine significantly reduced heart rate in 26 h old zebrafish embryos....

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Bibliographic Details
Published in:Reprod Toxicol
Main Authors: Kanungo, Jyotshnabala, Cuevas, Elvis, Ali, Syed F., Paule, Merle G.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470543/
https://ncbi.nlm.nih.gov/pubmed/22027688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reprotox.2011.10.004
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