Self-reactive T cells can escape clonal deletion in T-cell receptor V beta 8.1 transgenic mice.

To study the mechanisms of tolerance in detail, we have constructed transgenic mice expressing a V beta 8.1-D beta 2-J beta 2.3-C beta 2 T-cell receptor (TCR) gene. Since expression of V beta 8.1 is known to correlate with reactivity of CD4+CD8- T cells to minor lymphocyte-stimulating locus 1a (Mls-...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Yui, K, Komori, S, Katsumata, M, Siegel, R M, Greene, M I
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1990
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54698/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2402496/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.18.7135
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