Enhanced chondrogenesis of bone marrow-derived stem cells by using a combinatory cell therapy strategy with BMP-2/TGF-β1, hypoxia, and COL1A1/HtrA1 siRNAs

Mesenchymal stem cells (MSCs) hold promise for cartilage engineering. Here, we aimed to determine the best culture conditions to induce chondrogenesis of MSCs isolated from bone marrow (BM) of aged osteoarthritis (OA) patients. We showed that these BM-MSCs proliferate slowly, are not uniformly posit...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Legendre, Florence, Ollitrault, David, Gomez-Leduc, Tangni, Bouyoucef, Mouloud, Hervieu, Magalie, Gruchy, Nicolas, Mallein-Gerin, Frédéric, Leclercq, Sylvain, Demoor, Magali, Galéra, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469741/
https://ncbi.nlm.nih.gov/pubmed/28611369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03579-y
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