Mitochondrial DNA Damage Initiates Acute Lung Injury and Multi-Organ System Failure Evoked in Rats by Intra-tracheal Pseudomonas aeruginosa

Although studies in rat cultured pulmonary artery endothelial cells, perfused lungs, and intact mice support the concept that oxidative mitochondrial (mt) DNA damage triggers acute lung injury (ALI), it has not yet been determined whether enhanced mtDNA repair forestalls development of ALI and its p...

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Veröffentlicht in:Shock
Hauptverfasser: Lee, Yann-Leei, Obiako, Boniface, Gorodnya, Olena M., Ruchko, Mykhaylo V., Kuck, Jamie L., Pastukh, Viktor M., Wilson, Glenn L., Simmons, Jon D., Gillespie, Mark N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468468/
https://ncbi.nlm.nih.gov/pubmed/28125528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000838
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