Efficient Divergent Synthesis of New Immunostimulant 4″-Modified α-Galactosylceramide Analogues

[Image: see text] A synthesis strategy for the swift generation of 4″-modified α-galactosylceramide (α-GalCer) analogues is described, establishing a chemical platform to comprehensively investigate the structure–activity relationships (SAR) of this understudied glycolipid part. The strategy relies...

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Publié dans:ACS Med Chem Lett
Auteurs principaux: Janssens, Jonas, Decruy, Tine, Venken, Koen, Seki, Toshiyuki, Krols, Simon, Van der Eycken, Johan, Tsuji, Moriya, Elewaut, Dirk, Van Calenbergh, Serge
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2017
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467197/
https://ncbi.nlm.nih.gov/pubmed/28626526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00107
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