Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex

[Image: see text] Appropriate integration of cellular signals requires a delicate balance of ligand–target binding affinities. Increasing the level of residual structure in intrinsically disordered proteins (IDPs), which are overrepresented in these cellular processes, has been shown previously to e...

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Udgivet i:Biochemistry
Main Authors: Crabtree, Michael D., Borcherds, Wade, Poosapati, Anusha, Shammas, Sarah L., Daughdrill, Gary W., Clarke, Jane
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467178/
https://ncbi.nlm.nih.gov/pubmed/28425697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00179
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