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Uncoupling the folding and binding of an intrinsically disordered protein
The relationship between helical stability and binding affinity was examined for the intrinsically disordered transactivation domain (TAD) of the myeloblastosis oncoprotein, c-Myb and its ordered binding partner, KIX. A series of c-Myb mutants was designed to either increase or decrease helical stab...
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| 發表在: | J Mol Biol |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6082395/ https://ncbi.nlm.nih.gov/pubmed/29890118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.05.045 |
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