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Uncoupling the folding and binding of an intrinsically disordered protein
The relationship between helical stability and binding affinity was examined for the intrinsically disordered transactivation domain (TAD) of the myeloblastosis oncoprotein, c-Myb and its ordered binding partner, KIX. A series of c-Myb mutants was designed to either increase or decrease helical stab...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6082395/ https://ncbi.nlm.nih.gov/pubmed/29890118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.05.045 |
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