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Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex
[Image: see text] Appropriate integration of cellular signals requires a delicate balance of ligand–target binding affinities. Increasing the level of residual structure in intrinsically disordered proteins (IDPs), which are overrepresented in these cellular processes, has been shown previously to e...
Zapisane w:
| Wydane w: | Biochemistry |
|---|---|
| Główni autorzy: | , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American
Chemical Society
2017
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5467178/ https://ncbi.nlm.nih.gov/pubmed/28425697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00179 |
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