Subcutaneous Immunization with Fusion Protein DnaJ-ΔA146Ply without Additional Adjuvants Induces both Humoral and Cellular Immunity against Pneumococcal Infection Partially Depending on TLR4

Subunit vaccines that are poorly immunogenic are often combined with adjuvants for immunization. Our previous research identified a pneumolysin variant (ΔA146Ply), a Toll-like receptor 4 agonist, that was an effective adjuvant in the protection of fusion protein DnaJ-ΔA146Ply against mucosal Strepto...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Front Immunol
Main Authors: Su, Yufeng, Li, Dagen, Xing, Yan, Wang, Hong, Wang, Jian, Yuan, Jun, Wang, Xiaofang, Cui, Fang, Yin, Yibing, Zhang, Xuemei
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2017
נושאים:
Immunology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466963/
https://ncbi.nlm.nih.gov/pubmed/28659923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00686
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