Expression of Toll-Like Receptor 2 by Dendritic Cells Is Essential for the DnaJ-ΔA146Ply-Mediated Th1 Immune Response against Streptococcus pneumoniae

The fusion protein DnaJ-ΔA146Ply could induce cross-protective immunity against pneumococcal infection via mucosal and subcutaneous immunization in mice in the absence of additional adjuvants. DnaJ and Ply are both Toll-like receptor 4 (TLR4) but not TLR2 ligands. However, we found that TLR2(−/−) mi...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Wang, Xiaofang, Yuan, Taixian, Yuan, Jun, Su, Yufeng, Sun, Xiaoyu, Wu, Jingwen, Zhang, Hong, Min, Xun, Zhang, Xuemei, Yin, Yibing
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820941/
https://ncbi.nlm.nih.gov/pubmed/29229733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00651-17
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