Subcutaneous Immunization with Fusion Protein DnaJ-ΔA146Ply without Additional Adjuvants Induces both Humoral and Cellular Immunity against Pneumococcal Infection Partially Depending on TLR4

Subunit vaccines that are poorly immunogenic are often combined with adjuvants for immunization. Our previous research identified a pneumolysin variant (ΔA146Ply), a Toll-like receptor 4 agonist, that was an effective adjuvant in the protection of fusion protein DnaJ-ΔA146Ply against mucosal Strepto...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Su, Yufeng, Li, Dagen, Xing, Yan, Wang, Hong, Wang, Jian, Yuan, Jun, Wang, Xiaofang, Cui, Fang, Yin, Yibing, Zhang, Xuemei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466963/
https://ncbi.nlm.nih.gov/pubmed/28659923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00686
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