Mucosal Immunization with the Live Attenuated Vaccine SPY1 Induces Humoral and Th2-Th17-Regulatory T Cell Cellular Immunity and Protects against Pneumococcal Infection

Mucosal immunization with attenuated vaccine can protect against pneumococcal invasion infection, but the mechanism was unknown. Our study found that mucosal delivery with the live attenuated SPY1 vaccine strain can confer T cell- and B cell-dependent protection against pneumococcal colonization and...

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Udgivet i:Infect Immun
Main Authors: Xu, Xiuyu, Wang, Hong, Liu, Yusi, Wang, Yiping, Zeng, Lingbing, Wu, Kaifeng, Wang, Jianmin, Ma, Feng, Xu, Wenchun, Yin, Yibing, Zhang, Xuemei
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Microbial Immunity and Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288905/
https://ncbi.nlm.nih.gov/pubmed/25312946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02334-14
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