Mucosal Immunization with the Live Attenuated Vaccine SPY1 Induces Humoral and Th2-Th17-Regulatory T Cell Cellular Immunity and Protects against Pneumococcal Infection

Mucosal immunization with attenuated vaccine can protect against pneumococcal invasion infection, but the mechanism was unknown. Our study found that mucosal delivery with the live attenuated SPY1 vaccine strain can confer T cell- and B cell-dependent protection against pneumococcal colonization and...

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Dades bibliogràfiques
Publicat a:Infect Immun
Autors principals: Xu, Xiuyu, Wang, Hong, Liu, Yusi, Wang, Yiping, Zeng, Lingbing, Wu, Kaifeng, Wang, Jianmin, Ma, Feng, Xu, Wenchun, Yin, Yibing, Zhang, Xuemei
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Microbial Immunity and Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288905/
https://ncbi.nlm.nih.gov/pubmed/25312946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02334-14
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