Mucosal Immunization with the Live Attenuated Vaccine SPY1 Induces Humoral and Th2-Th17-Regulatory T Cell Cellular Immunity and Protects against Pneumococcal Infection

Mucosal immunization with attenuated vaccine can protect against pneumococcal invasion infection, but the mechanism was unknown. Our study found that mucosal delivery with the live attenuated SPY1 vaccine strain can confer T cell- and B cell-dependent protection against pneumococcal colonization and...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Xu, Xiuyu, Wang, Hong, Liu, Yusi, Wang, Yiping, Zeng, Lingbing, Wu, Kaifeng, Wang, Jianmin, Ma, Feng, Xu, Wenchun, Yin, Yibing, Zhang, Xuemei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288905/
https://ncbi.nlm.nih.gov/pubmed/25312946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02334-14
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