Mucosal Immunization with the Live Attenuated Vaccine SPY1 Induces Humoral and Th2-Th17-Regulatory T Cell Cellular Immunity and Protects against Pneumococcal Infection

Mucosal immunization with attenuated vaccine can protect against pneumococcal invasion infection, but the mechanism was unknown. Our study found that mucosal delivery with the live attenuated SPY1 vaccine strain can confer T cell- and B cell-dependent protection against pneumococcal colonization and...

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Xu, Xiuyu, Wang, Hong, Liu, Yusi, Wang, Yiping, Zeng, Lingbing, Wu, Kaifeng, Wang, Jianmin, Ma, Feng, Xu, Wenchun, Yin, Yibing, Zhang, Xuemei
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288905/
https://ncbi.nlm.nih.gov/pubmed/25312946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02334-14
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