Mucosal Immunization with Recombinant Fusion Protein DnaJ-ΔA146Ply Enhances Cross-Protective Immunity against Streptococcus pneumoniae Infection in Mice via Interleukin 17A

Pneumolysin (Ply) and its variants are protective against pneumococcal infections in animal models, and as a Toll-like receptor 4 agonist, pneumolysin has been reported to be a mucosal adjuvant. DnaJ has been approved as a useful candidate vaccine protein; we therefore designed novel fusion proteins...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Yusi, Wang, Hong, Zhang, Shuai, Zeng, Lingbin, Xu, Xiuyu, Wu, Kaifeng, Wang, Wei, Yin, Nanlin, Song, Zhixin, Zhang, Xuemei, Yin, Yibing
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993385/
https://ncbi.nlm.nih.gov/pubmed/24491576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01391-13
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