Subcutaneous Immunization with Fusion Protein DnaJ-ΔA146Ply without Additional Adjuvants Induces both Humoral and Cellular Immunity against Pneumococcal Infection Partially Depending on TLR4

Subunit vaccines that are poorly immunogenic are often combined with adjuvants for immunization. Our previous research identified a pneumolysin variant (ΔA146Ply), a Toll-like receptor 4 agonist, that was an effective adjuvant in the protection of fusion protein DnaJ-ΔA146Ply against mucosal Strepto...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Su, Yufeng, Li, Dagen, Xing, Yan, Wang, Hong, Wang, Jian, Yuan, Jun, Wang, Xiaofang, Cui, Fang, Yin, Yibing, Zhang, Xuemei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466963/
https://ncbi.nlm.nih.gov/pubmed/28659923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00686
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