The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland

Salivary glands, such as submandibular glands (SMGs), are composed of branched epithelial ductal networks that terminate in acini that together produce, transport and secrete saliva. Here, we show that the transcriptional regulator Yap, a key effector of the Hippo pathway, is required for the proper...

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Veröffentlicht in:eLife
Hauptverfasser: Szymaniak, Aleksander D, Mi, Rongjuan, McCarthy, Shannon E, Gower, Adam C, Reynolds, Taylor L, Mingueneau, Michael, Kukuruzinska, Maria, Varelas, Xaralabos
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2017
Schlagworte:
Developmental Biology and Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466420/
https://ncbi.nlm.nih.gov/pubmed/28492365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23499
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