The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland

Salivary glands, such as submandibular glands (SMGs), are composed of branched epithelial ductal networks that terminate in acini that together produce, transport and secrete saliva. Here, we show that the transcriptional regulator Yap, a key effector of the Hippo pathway, is required for the proper...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Szymaniak, Aleksander D, Mi, Rongjuan, McCarthy, Shannon E, Gower, Adam C, Reynolds, Taylor L, Mingueneau, Michael, Kukuruzinska, Maria, Varelas, Xaralabos
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Developmental Biology and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466420/
https://ncbi.nlm.nih.gov/pubmed/28492365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23499
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