The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland

Salivary glands, such as submandibular glands (SMGs), are composed of branched epithelial ductal networks that terminate in acini that together produce, transport and secrete saliva. Here, we show that the transcriptional regulator Yap, a key effector of the Hippo pathway, is required for the proper...

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Pubblicato in:eLife
Autori principali: Szymaniak, Aleksander D, Mi, Rongjuan, McCarthy, Shannon E, Gower, Adam C, Reynolds, Taylor L, Mingueneau, Michael, Kukuruzinska, Maria, Varelas, Xaralabos
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2017
Soggetti:
Developmental Biology and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466420/
https://ncbi.nlm.nih.gov/pubmed/28492365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23499
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