Ribavirin Resistance in Hepatitis C Virus Replicon-Containing Cell Lines Conferred by Changes in the Cell Line or Mutations in the Replicon RNA

Ribavirin (RBV), used in combination with alpha interferon to treat hepatitis C virus (HCV) infections, is a guanosine nucleotide analog that can increase the error rate of viral RNA-dependent RNA polymerases, imbalance intracellular nucleotide pools, and cause toxicity in many cell types. To determ...

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Bibliographic Details
Main Authors: Pfeiffer, Julie K., Kirkegaard, Karla
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC546591/
https://ncbi.nlm.nih.gov/pubmed/15681435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.4.2346-2355.2005
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