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A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity

Ribavirin is a nucleotide analog that can be incorporated by viral polymerases, causing mutations by allowing base mismatches. It is currently used therapeutically as an antiviral drug during hepatitis C virus infections. During the amplification of poliovirus genomic RNA or hepatitis C replicons, e...

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מידע ביבליוגרפי
Main Authors: Pfeiffer, Julie K., Kirkegaard, Karla
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2003
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC165868/
https://ncbi.nlm.nih.gov/pubmed/12754380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1232294100
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