A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity
Ribavirin is a nucleotide analog that can be incorporated by viral polymerases, causing mutations by allowing base mismatches. It is currently used therapeutically as an antiviral drug during hepatitis C virus infections. During the amplification of poliovirus genomic RNA or hepatitis C replicons, e...
Na minha lista:
| Udgivet i: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2003
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165868/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12754380/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1232294100 |
| Tags: |
Ingen Tags, Vær først til at tagge denne postø!
|