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The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis

The proteasome-associated deubiquitinating enzyme Usp14/Ubp6 inhibits protein degradation by catalyzing substrate deubiquitination and by poorly understood allosteric actions. However, upon binding a ubiquitin chain, Usp14 enhances proteasomal degradation by stimulating ATP and peptide degradation....

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Kim, Hyoung Tae, Goldberg, Alfred L.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465503/
https://ncbi.nlm.nih.gov/pubmed/28416611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.763128
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