The Behçet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing

A low-activity variant of endoplasmic reticulum aminopeptidase 1 (ERAP1), Hap10, is associated with the autoinflammatory disorder Behçet's disease (BD) in epistasis with HLA-B*51, which is the main risk factor for this disorder. The role of Hap10 in BD pathogenesis is unknown. We sought to defi...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Guasp, Pablo, Barnea, Eilon, González-Escribano, M. Francisca, Jiménez-Reinoso, Anaïs, Regueiro, José R., Admon, Arie, López de Castro, José A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465491/
https://ncbi.nlm.nih.gov/pubmed/28446606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.789180
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