Substantial Influence of ERAP2 on the HLA-B*40:02 Peptidome: Implications for HLA-B*27-Negative Ankylosing Spondylitis

HLA-B*40:02 is one of a few major histocompatibility complex class I (MHC-I) molecules associated with ankylosing spondylitis (AS) independently of HLA-B*27. The endoplasmic reticulum aminopeptidase 2 (ERAP2), an enzyme that process MHC-I ligands and preferentially trims N-terminal basic residues, i...

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Publicado en:Mol Cell Proteomics
Autores principales: Lorente, Elena, Redondo-Antón, Jennifer, Martín-Esteban, Adrian, Guasp, Pablo, Barnea, Eilon, Lauzurica, Pilar, Admon, Arie, López de Castro, José A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2019
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823859/
https://ncbi.nlm.nih.gov/pubmed/31530632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA119.001710
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