Redundancy and Complementarity between ERAP1 and ERAP2 Revealed by their Effects on the Behcet's Disease-associated HLA-B*51 Peptidome

The endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 trim peptides to be loaded onto HLA molecules, including the main risk factor for Behçet's disease HLA-B*51. ERAP1 is also a risk factor among HLA-B*51-positive individuals, whereas no association is known with ERAP2. This study addresse...

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Veröffentlicht in:Mol Cell Proteomics
Hauptverfasser: Guasp, Pablo, Lorente, Elena, Martín-Esteban, Adrian, Barnea, Eilon, Romania, Paolo, Fruci, Doriana, Kuiper, Jonas J. W., Admon, Arie, López de Castro, José A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682995/
https://ncbi.nlm.nih.gov/pubmed/31092671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA119.001515
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