Allele-specific Alterations in the Peptidome Underlie the Joint Association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy

Virtually all patients of the rare inflammatory eye disease birdshot chorioretinopathy (BSCR) carry the HLA-A*29:02 allele. BSCR is also associated with endoplasmic reticulum aminopeptidase 2 (ERAP2), an enzyme involved in processing HLA class I ligands, thus implicating the A*29:02 peptidome in thi...

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Foilsithe in:Mol Cell Proteomics
Main Authors: Sanz-Bravo, Alejandro, Martín-Esteban, Adrian, Kuiper, Jonas J. W., García-Peydró, Marina, Barnea, Eilon, Admon, Arie, López de Castro, José A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Biochemistry and Molecular Biology 2018
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072538/
https://ncbi.nlm.nih.gov/pubmed/29769354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.000778
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