The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)

Chemotherapeutic nucleoside analogs, such as Ara-C, 5-Fluorouracil (5-FU) and Trifluridine (FTD), are frequently incorporated into DNA by the replicative DNA polymerases. However, it remains unclear how this incorporation kills cycling cells. There are two possibilities: Nucleoside analog triphospha...

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Publicado en:Oncotarget
Autores principales: Tsuda, Masataka, Terada, Kazuhiro, Ooka, Masato, Kobayashi, Koji, Sasanuma, Hiroyuki, Fujisawa, Ryo, Tsurimoto, Toshiki, Yamamoto, Junpei, Iwai, Shigenori, Kadoda, Kei, Akagawa, Remi, Huang, Shar-Yin Naomi, Pommier, Yves, Sale, Julian E., Takeda, Shunichi, Hirota, Kouji
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464882/
https://ncbi.nlm.nih.gov/pubmed/28380422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16508
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