In vivo evidence for translesion synthesis by the replicative DNA polymerase δ

The intolerance of DNA polymerase δ (Polδ) to incorrect base pairing contributes to its extremely high accuracy during replication, but is believed to inhibit translesion synthesis (TLS). However, chicken DT40 cells lacking the POLD3 subunit of Polδ are deficient in TLS. Previous genetic and biochem...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Hirota, Kouji, Tsuda, Masataka, Mohiuddin, Tsurimoto, Toshiki, Cohen, Isadora S., Livneh, Zvi, Kobayashi, Kaori, Narita, Takeo, Nishihara, Kana, Murai, Junko, Iwai, Shigenori, Guilbaud, Guillaume, Sale, Julian E., Takeda, Shunichi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009730/
https://ncbi.nlm.nih.gov/pubmed/27185888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw439
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