In vivo evidence for translesion synthesis by the replicative DNA polymerase δ

The intolerance of DNA polymerase δ (Polδ) to incorrect base pairing contributes to its extremely high accuracy during replication, but is believed to inhibit translesion synthesis (TLS). However, chicken DT40 cells lacking the POLD3 subunit of Polδ are deficient in TLS. Previous genetic and biochem...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Hirota, Kouji, Tsuda, Masataka, Mohiuddin, Tsurimoto, Toshiki, Cohen, Isadora S., Livneh, Zvi, Kobayashi, Kaori, Narita, Takeo, Nishihara, Kana, Murai, Junko, Iwai, Shigenori, Guilbaud, Guillaume, Sale, Julian E., Takeda, Shunichi
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009730/
https://ncbi.nlm.nih.gov/pubmed/27185888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw439
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