The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ

The replicative DNA polymerase Polδ consists of a catalytic subunit POLD1/p125 and three regulatory subunits POLD2/p50, POLD3/p66 and POLD4/p12. The ortholog of POLD3 in Saccharomyces cerevisiae, Pol32, is required for a significant proportion of spontaneous and UV-induced mutagenesis through its ad...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Hirota, Kouji, Yoshikiyo, Kazunori, Guilbaud, Guillaume, Tsurimoto, Toshiki, Murai, Junko, Tsuda, Masataka, Phillips, Lara G., Narita, Takeo, Nishihara, Kana, Kobayashi, Kaori, Yamada, Kouich, Nakamura, Jun, Pommier, Yves, Lehmann, Alan, Sale, Julian E., Takeda, Shunichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330384/
https://ncbi.nlm.nih.gov/pubmed/25628356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv023
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