P08.19 Resistance towards the MDM2 inhibitor idasanutlin is mediated via the NFkB pathway and IGFBP1 upregulation in glioblastoma

Background: Dysregulation of p53 pathway is common in glioma. Frequent causes are p53 mutations or overexpression of the oncogene MDM2 in p53 wildtype tumors. Idasanutlin is a MDM2 inhibitor, which is currently under investigation for multiple myeloma and acute myeloid leukemia, but of principal int...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Hertenstein, A., Chiblak, S., Hielscher, T., Ciprut, S., Lemke, D., Thomé, C., Kessler, T., Abdollahi, A., Platten, M., Wick, W.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
POSTER PRESENTATIONS
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5463780/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox036.209
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