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P08.19 Resistance towards the MDM2 inhibitor idasanutlin is mediated via the NFkB pathway and IGFBP1 upregulation in glioblastoma
Background: Dysregulation of p53 pathway is common in glioma. Frequent causes are p53 mutations or overexpression of the oncogene MDM2 in p53 wildtype tumors. Idasanutlin is a MDM2 inhibitor, which is currently under investigation for multiple myeloma and acute myeloid leukemia, but of principal int...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5463780/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox036.209 |
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