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Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
Therapeutic application of the recently discovered small interfering RNA (siRNA) gene silencing phenomenon will be dependent on improvements in molecule bio-stability, specificity and delivery. To address these issues, we have systematically modified siRNA with the synthetic RNA-like high affinity n...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC546170/ https://ncbi.nlm.nih.gov/pubmed/15653644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki193 |
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