Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

Therapeutic application of the recently discovered small interfering RNA (siRNA) gene silencing phenomenon will be dependent on improvements in molecule bio-stability, specificity and delivery. To address these issues, we have systematically modified siRNA with the synthetic RNA-like high affinity n...

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Hlavní autoři: Elmén, Joacim, Thonberg, Håkan, Ljungberg, Karl, Frieden, Miriam, Westergaard, Majken, Xu, Yunhe, Wahren, Britta, Liang, Zicai, Ørum, Henrik, Koch, Troels, Wahlestedt, Claes
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2005
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC546170/
https://ncbi.nlm.nih.gov/pubmed/15653644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki193
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