Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones

Splicing is catalyzed by the spliceosome, a complex of five major small nuclear ribonucleoprotein particles (snRNPs). The pre-mRNA splicing factor PRPF8 is a crucial component of the U5 snRNP, and together with EFTUD2 and SNRNP200, it forms a central module of the spliceosome. Using quantitative pro...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Malinová, Anna, Cvačková, Zuzana, Matějů, Daniel, Hořejší, Zuzana, Abéza, Claire, Vandermoere, Franck, Bertrand, Edouard, Staněk, David, Verheggen, Céline
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461031/
https://ncbi.nlm.nih.gov/pubmed/28515276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201701165
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