Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery

Once introduced in the organism, the interaction of nanoparticles with various biomolecules strongly impacts their fate. Here we show that nanoparticles made of the squalene derivative of gemcitabine (SQGem) interact with lipoproteins (LPs), indirectly enabling the targeting of cancer cells with hig...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Sobot, Dunja, Mura, Simona, Yesylevskyy, Semen O., Dalbin, Laura, Cayre, Fanny, Bort, Guillaume, Mougin, Julie, Desmaële, Didier, Lepetre-Mouelhi, Sinda, Pieters, Grégory, Andreiuk, Bohdan, Klymchenko, Andrey S., Paul, Jean-Louis, Ramseyer, Christophe, Couvreur, Patrick
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459998/
https://ncbi.nlm.nih.gov/pubmed/28555624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15678
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