Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery

Once introduced in the organism, the interaction of nanoparticles with various biomolecules strongly impacts their fate. Here we show that nanoparticles made of the squalene derivative of gemcitabine (SQGem) interact with lipoproteins (LPs), indirectly enabling the targeting of cancer cells with hig...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Sobot, Dunja, Mura, Simona, Yesylevskyy, Semen O., Dalbin, Laura, Cayre, Fanny, Bort, Guillaume, Mougin, Julie, Desmaële, Didier, Lepetre-Mouelhi, Sinda, Pieters, Grégory, Andreiuk, Bohdan, Klymchenko, Andrey S., Paul, Jean-Louis, Ramseyer, Christophe, Couvreur, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459998/
https://ncbi.nlm.nih.gov/pubmed/28555624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15678
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