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A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine
The clinical use of endogenous neuropeptides has historically been limited due to pharmacokinetic issues, including plasma stability and blood-brain barrier permeability. In this study, we show that the rapidly metabolized Leu-enkephalin (LENK) neuropeptide may become pharmacologically efficient owi...
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| Veröffentlicht in: | Sci Adv |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Association for the Advancement of Science
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6374102/ https://ncbi.nlm.nih.gov/pubmed/30788432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau5148 |
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