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Curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine

In this work the permeability of a model asymmetric plasma membrane, for ions, water and the anti-cancer drugs cisplatin and gemcitabine is studied by means of all-atom molecular dynamics simulations. It is shown for the first time that permeability of the highly curved membrane increases from one t...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yesylevskyy, Semen, Rivel, Timothée, Ramseyer, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868207/
https://ncbi.nlm.nih.gov/pubmed/31748538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53952-2
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