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Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity
Notch receptor activation initiates cell fate decisions, and is distinctive in its reliance on mechanical force and protein glycosylation. The 2.5 angstrom crystal structure of the extracellular interacting regions of Notch1 complexed with an engineered, high-affinity variant of Jagged1 (Jag1) revea...
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| Pubblicato in: | Science |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5459593/ https://ncbi.nlm.nih.gov/pubmed/28254785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf9739 |
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