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Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors

A cation-π interaction between the ammonium group of an agonist and a conserved tryptophan termed TrpB is a near universal feature of agonist binding to nicotinic acetylcholine receptors (nAChRs). TrpB is one of five residues that form the aromatic box of the agonist binding site, and for the protot...

詳細記述

保存先:
書誌詳細
出版年:eNeuro
主要な著者: Post, Michael R., Tender, Gabrielle S., Lester, Henry A., Dougherty, Dennis A.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458768/
https://ncbi.nlm.nih.gov/pubmed/28589175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0032-17.2017
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