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Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors
A cation-π interaction between the ammonium group of an agonist and a conserved tryptophan termed TrpB is a near universal feature of agonist binding to nicotinic acetylcholine receptors (nAChRs). TrpB is one of five residues that form the aromatic box of the agonist binding site, and for the protot...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | eNeuro |
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| Κύριοι συγγραφείς: | , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Society for Neuroscience
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5458768/ https://ncbi.nlm.nih.gov/pubmed/28589175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0032-17.2017 |
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