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Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors

A cation-π interaction between the ammonium group of an agonist and a conserved tryptophan termed TrpB is a near universal feature of agonist binding to nicotinic acetylcholine receptors (nAChRs). TrpB is one of five residues that form the aromatic box of the agonist binding site, and for the protot...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eNeuro
Prif Awduron: Post, Michael R., Tender, Gabrielle S., Lester, Henry A., Dougherty, Dennis A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458768/
https://ncbi.nlm.nih.gov/pubmed/28589175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0032-17.2017
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