Nicotine Binding to Brain Receptors Requires a Strong Cation-π Interaction

Nicotine addiction begins with high-affinity binding of nicotine to acetylcholine (ACh) receptors in the brain. The end result is over 4,000,000 smoking-related deaths annually worldwide and the largest source of preventable mortality in developed countries. Stress reduction, pleasure, improved cogn...

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Hlavní autoři: Xiu, Xinan, Puskar, Nyssa L., Shanata, Jai A. P., Lester, Henry A., Dougherty, Dennis A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755585/
https://ncbi.nlm.nih.gov/pubmed/19252481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07768
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