Two Neuronal Nicotinic Acetylcholine Receptors, α4β4 and α7, Show Differential Agonist Binding Modes

Nicotinic acetylcholine receptors (nAChRs) are pentameric, neurotransmitter-gated ion channels responsible for rapid excitatory neurotransmission in the central and peripheral nervous systems, resulting in skeletal muscle tone and various cognitive effects in the brain. These complex proteins are ac...

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Bibliographic Details
Main Authors: Puskar, Nyssa L., Xiu, Xinan, Lester, Henry A., Dougherty, Dennis A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077659/
https://ncbi.nlm.nih.gov/pubmed/21343288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.206565
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