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Probing the Effects of Residues Located Outside the Agonist Binding Site on Drug-Receptor Selectivity in the Nicotinic Receptor

The nicotinic acetylcholine receptors (nAChRs) are a family of closely related but pharmacologically distinct neurotransmitter-gated ion channels. They are therapeutic targets for a wide range of neurological disorders, and a key issue in drug development is selective targeting among the greater tha...

詳細記述

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書誌詳細
主要な著者: Puskar, Nyssa L., Lester, Henry A., Dougherty, Dennis A.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356501/
https://ncbi.nlm.nih.gov/pubmed/22296725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200448j
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