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Conformational dynamics in penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus, allosteric communication network and enablement of catalysis

The mechanism of the β-lactam antibacterials is the functionally irreversible acylation of the enzymes that catalyze the cross-linking steps in the biosynthesis of their peptidoglycan cell wall. The Gram-positive pathogen Staphylococcus aureus uses one primary resistance mechanism. An enzyme, called...

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Main Authors: Mahasenan, Kiran V., Molina, Rafael, Bouley, Renee, Batuecas, María T., Fisher, Jed F., Hermoso, Juan A., Chang, Mayland, Mobashery, Shahriar
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458748/
https://ncbi.nlm.nih.gov/pubmed/28099001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b12565
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