How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function

The expression of penicillin binding protein 2a (PBP2a) is the basis for the broad clinical resistance to the β-lactam antibiotics by methicillin-resistant Staphylococcus aureus (MRSA). The high-molecular mass penicillin binding proteins of bacteria catalyze in separate domains the transglycosylase...

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Bibliographic Details
Main Authors: Otero, Lisandro H., Rojas-Altuve, Alzoray, Llarrull, Leticia I., Carrasco-López, Cesar, Kumarasiri, Malika, Lastochkin, Elena, Fishovitz, Jennifer, Dawley, Matthew, Hesek, Dusan, Lee, Mijoon, Johnson, Jarrod W., Fisher, Jed F., Chang, Mayland, Mobashery, Shahriar, Hermoso, Juan A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800995/
https://ncbi.nlm.nih.gov/pubmed/24085846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300118110
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